A product derived from the Cannabis plant, that contain trace amounts of minor cannabinoids, cannabis oil, and very low or zero amounts of THC (less than 0.3%).

The use, sale, and possession of cannabis over 0.3% THC in the United states, despite state laws, is illegal under federal law. As a Schedule I drug, under the federal Controlled Substance Act of 1970, any medicine or supplement that has no accepted medical use and has a high potential for abuse and physical or psychological dependence is considered a Schedule I drug. Prior to December 2018, it was illegal to grow hemp in the U.S. In December 2018, the Hemp Farming Act was included in the 2018 Farm Bill and passed.

Often referred to as a ‘COA,’ it is an authenticated document that presents the analytical results of a specific test on a product specific batch or lot.

It is testing that has been completed from unbiased testing laboratory, that does not have a business, financial or other relationship to the product or company in question.

CBD interacts with the same receptors that are bound to the neurotransmitters associated with the Endocannabinoid System. CBD causes chemical changes by blocking receptors. It tends to have low affinity for both CB1 and CB2 receptors, and instead acts as an indirect antagonist of agonists. This means that CBD sits imperfectly inside the receptors, not activating them but supporting other chemical messengers from binding to them. Studies have shown that CBD may reduce the negative effects of certain medical conditions which include: Arthritis Anxiety Appetite Allergies & Itching Skin Conditions Cancer Fatty Tumors Glaucoma Inflammatory Bowel Disease Digestive issues Seizures & Epilepsy* Joints & Mobility Pain & Inflammation Noise Phobia *As of 2020, three Cannabis derived prescription medications have been approved by the FDA.

The Endocannabinoid system is a biological system composed of endocannabinoids, which are lipid-based neurotransmitters that bind to receptors and receptor proteins that are expressed throughout the vertebrate central and peripheral nervous systems. The endocannabinoid system remains under preliminary research, but may be involved in regulating physiological and cognitive processes, including fertility, pregnancy, appetite, pain-sensation, mood, immunity and memory.

It is a plant of the Cannabaceae family and contains more than eighty biologically active chemical compounds. The most commonly known compounds are delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD).

It is the process of removing something by forcing it out. In terms of removing the oil from Cannabis plants, carbon dioxide, steam distillation, or hydrocarbon/natural solvents are the three methods that are used.

CBD and THC are two separate cannabinoids and one cannot contain the other. Each Cannabis plant type, such as Hemp and Marijuana, contain varying degrees of cannabinoids. Not all plant types contain THC, but all plant types contain CBD.

American Veterinary Medical Association (AVMA) and Veterinary Medical Examiners (VME) restricts what Veterinarians can prescribe, dispense or recommend in terms of Cannabis products. Hemp is in the Cannabis family of plants and although Hemp is legal in all 50 states, the AVMA and VME will not allow Veterinarians to use or recommend a substance within this class of plants. Veterinarians have urged the AVME and VME to lift restrictions concerning pet CBD due to the increase of clinical trials and research in this area, as well as the increase of pet owners seeking guidance. In 2018, California’s governor signed into law Assembly Bill 2215. The bill prohibits the Veterinary Medical Board from disciplining, or denying, revoking, or suspending the license of a licensed Veterinarian solely for discussing the use of Cannabis for medicinal purposes. I used the following sources to obtain the information used in this article: USFDA.gov Merriam-Webster Dictionary Chemical and Engineering News Wikipedia Health.Harvard.edu Veterinary Medical Board Alcohol and Drug Foundation

THC is the abbreviation of tetrahydrocannabinol which produces a psychoactive response when taken. THC is one of at least 113 cannabinoids identified in Cannabis. THC is the principal constituent of cannabis and is thought to be involved in the plant's self-defense against insects, ultraviolet light and environmental stress.

A product derived from the Cannabis plant, that contains moderate amounts of cannabinoids, cannabis oil, and very low or zero amounts of THC (less than 0.3%).

Vegan refers to anything that does not contain a product that is directly or indirectly associated with the life of an animal.

Isolate refers to the oil derived from the Cannabis plant that does not contain cannabinoids or terpene.

A genetically modified organism (GMO) is any organism whose genetic material has been altered using genetic engineering techniques.

The 2014 farm bill defined hemp as the sativa plant from Cannabis, whether growing or not, with a delta-9 tetrahydrocannabinol concentration of not more than 0.3 percent on a dry weight basis.

No.

It is any part of the flower buds and leaves of the female hemp plant, whether growing or not. THC is found throughout all of the aerial parts (leaves and flowers). In order for hemp to be defined as hemp, that is contained in a product used within the United States, the THC percentage must remain under 0.3%. Hemp growers use only the stalk when producing a product that is legally is defined as hemp.

An ‘Entourage Effect’ is also known as a synergistic effect. Synergy occurs when the interaction of two or more substances produces a combined effect, greater than the sum of their separate effects.

In relation to farming a product can be called organic if it's certified to have grown on soil that had no prohibited substances applied for three years prior to harvest. Prohibited substances include most synthetic fertilizers and pesticides.

They are substances, or chemicals defined as drugs with no currently accepted medical use and a high potential for abuse. Some examples of Schedule I drugs are: heroin, lysergic acid diethylamide (LSD), marijuana (cannabis), 3,4-methylenedioxymethamphetamine (ecstasy), methaqualone, and peyote. *Because the FDA has approved three Cannabis-derived prescription medications, the Federal Government is currently evaluating Cannabis as it does have accepted medical use.

Medium-chain triglycerides (MCT) are triglycerides with two or three fatty acids having an aliphatic tail of 6–12 carbon atoms. Pure cannabis oil is extremely potent. MCTs such as coconut oil are added to dilute the end product, making it easier to dose.

CBD is the abbreviation of Cannabidiol. CBD is a cannabinoid and is one of 113 active cannabinoids identified in the Cannabis Sativa plant. Cannabaceae is a small family of flowering plants. The family includes 170 species grouped in 11 groups and Cannabis is one of those groups. Cannabis Sativa is in the Cannabis group.

Cannabis a term for a genus of plants that includes the marijuana and hemp plant. Hemp and hemp derived CBD are federally legal while marijuana and its derivatives are not. The cannabis plant has two main subspecies, Cannabis indica and Cannabis sativa, and they can be differentiated by their different physical characteristics. Indica-dominant strains are short plants with broad, dark green leaves and have higher cannabidiol content than the sativa plants in which THC content is higher. Sativa-dominant strains are usually taller and have thin leaves with a pale green color. In the plant, cannabinoids are synthesized and accumulated as cannabinoid acids, but when the herbal product is dried, stored and heated, the acids decarboxylized. In 1971, a double-blind study with 40 healthy volunteers received orally administered d-9-THC and CBD were given independently and the mixtures of the two together. Pulse rate, time production tasks and psychological reactions were measured. D-9-THC alone increased pulse rate, disturbed time tasks and induced strong psychological reactions in the subjects, CBD alone provoked no such effects. However, CBD was efficient in blocking most of the effects of d-9-THC when both drugs were given together. Published results of this study, inspired the need for more clinical trials. In 1971, the Controlled Substance Act was formed which halted further development in this area.

The endocannabinoid system is one of the largest receptor systems in the mammalian body and is responsible for maintaining homeostasis. The ECS is comprised of endogenous cannabinoids, cannabinoid receptors and enzymes responsible for synthesis and degradation of endocannabinoids. It is a set of receptors, the CB1 and CB2 receptors. Much of the ongoing research in this area is looking at how these molecules will affect the endocannabinoid system. The endocannabinoid system has been found to be pervasive in mammalian species. It has also been described in invertebrate species as primitive as the Hydra. Insects, apparently, are devoid of this, otherwise, ubiquitous system that provides homeostatic balance to the nervous and immune systems, as well as many other organ systems. The endocannabinoid system (ECS) includes three parts (1) endogenous ligands, (2) G-protein coupled receptors (GPCRs), and (3) enzymes to degrade and recycle the ligands. Two endogenous molecules have been discovered as ligands in the ECS thus far. The endocannabinoids are anandamide and 2-AG. In addition, two G-coupled protein receptors (GPCR) is part of this system, with other putative GPC being considered.

Isolate is the purest form of extracted cannabinoids, a crystalline powder with a purity of 99.9%. It is created through additional solvent processes after distillation. The additional processing steps are expensive and the end result is extreme purity of the final product.

Full Spectrum describes the maximum amount of native phytochemicals retained during extraction, including THC. There are no precise regulatory definitions, but the goal is to remove extraneous lipids while retaining an identical ratio of cannabinoids, terpenes, and flavonoids from the original plant source material (which can only be verified by testing the material before and after the extraction). True full spectrum extracts are rare: most extractions lose significant terpenes and flavonoids during processing because they are much more volatile than cannabinoids. Ethanol and very low heat – the Rick Simpson oil (RSO) method or whole plant oil – or an extremely long vacuum extraction process can yield full spectrum extracts.

Distillate takes quite the opposite approach of full spectrum, seeking to remove everything but the cannabinoid(s) of interest. After undergoing solvent extraction, the concentrated oil is run (often multiple times) through the short-path distillation process described above, to purify it. Some suppliers will advertise “full-spectrum distillate” but this is contradictory. If terpenes or other bioactives are reintroduced after distillation, the product is sometimes also called broad spectrum.

Terpenes are a set of molecules produced by many plants that add to the aroma of different fruits, flowers and plants in general. They are of a large group of volatile unsaturated hydrocarbons found in the essential oils of plants, especially conifers and citrus trees. They are based on a cyclic molecule having the formula C10H16, comprise more than 30,000 compounds and may have calming and anti-inflammatory properties. Some terpenes include Ocimene, Pinene, Terpinene, Limonene, Caryophyllene, Lonalool and Eucalyptol.

Cannabinoids are naturally occurring compounds found in the Cannabis sativa plant. Of the over 480 different compounds present in the plant, only around 66 are termed cannabinoids. Cannabidiol is a phytocannabinoid derived from Cannabis species, which is devoid of psychoactive activity, with analgesic, anti-inflammatory, antineoplastic and chemo-preventive activities. Upon administration, cannabidiol (CBD) exerts its anti-proliferative, anti-angiogenic and pro-apoptotic activity through various mechanisms, which likely do not involve signaling by cannabinoid receptor 1 (CB1), CB2, or vanilloid receptor 1. CBD stimulates endoplasmic reticulum (ER) stress and inhibits AKT/mTOR signaling, thereby activating autophagy and promoting apoptosis. In addition, CBD enhances the generation of reactive oxygen species (ROS), which further enhances apoptosis. This agent also upregulates the expression of intercellular adhesion molecule 1 (ICAM-1) and tissue inhibitor of matrix metalloproteinases-1 (TIMP1) and decreases the expression of inhibitor of DNA binding 1 (ID-1). This inhibits cancer cell invasiveness and metastasis. CBD may also activate the transient receptor potential vanilloid type 2 (TRPV2), which may increase the uptake of various cytotoxic agents in cancer cells. The analgesic effect of CBD is mediated through the binding of this agent to and activation of CB1. The most notable cannabinoid is the phytocannabinoid tetrahydrocannabinol (THC) (Delta9-THC or Delta8-THC), the primary psychoactive compound in cannabis. The cannabinoids are separated into the following subclasses: Cannabigerols (CBG) Cannabichromenes (CBC) Cannabidiol (CBD) Tetrahydrocannabinol (THC) Cannabinol (CBN) Cannabinodiol (CBDL) Other cannabinoids including cannabicyclol (CBL), cannabielsoin (CBE) and cannabitriol (CBT)

This refers to the synergy found when a full or complete spectrum of cannabinoids and terpenes interact with ECS related enzymes. There is evidence that some cannabinoids boost the effects of other cannabinoids. Dr. Jordan Tishler MD, expert cannabis physician, and Instructor of Medicine at Harvard Medical School, states “The entourage effect has been proven but overgeneralized. There is irrefutable evidence, for example, that CBD … modulates the effects of THC at the main receptor site. The entourage effect also verifies that whole-plant cannabis products offers increased therapy but ideas that other chemicals are important for CBD to work are unsupported at present.”

These are the set of molecules that are coming from plants that work on the endocannabinoid system, as opposed to endocannabinoids or endogenous ligands, which are molecules created by the body to work on the endocannabinoid system. “Cannabinoids” is often used to refer to either endogenously produced or plant produced. A phytocannabinoids as any plant-derived natural product capable of either directly interacting with cannabinoid receptors or sharing chemical similarity with cannabinoids or both.

This is an expansion of the ECS, which includes other receptors that endogenous or plant-based cannabinoids bond with, such as the TRPV, opioid, serotonin, and nuclear receptors. Among these compounds, cannabidiol (CBD), cannabidivarin (CBDV), and THC propyl homologue D-tetrahydrocannabivarin (THCV) are the ones that have been most tested in clinical studies. In addition, an eCBS has been discovered that encompasses several non-eCB long-chain fatty acid amides which include: (i) the congeners of anandamide and 2-AG; the N-acyl-aminoacids; acylated neurotransmitters such as the N-acyl-dopamines and N-acyl-serotonins; and the primary fatty acid amides. These lipid mediators often share with anandamide and 2-AG biosynthetic. This expanded eCBS, including more than 100 lipid mediators, 20 enzymes, and 20 receptors, is known as the endocannabinoidome.

The abbreviation of CBD - people both in-and-out of the industry use this term incorrectly. Cannabidiol (CBD) is a phytocannabinoid and was discovered in 1940. It is one of 113 identified cannabinoids in cannabis plants and accounts for up to 40% of the plant's extract.

Broad Spectrum applies to extractions which aim to retain a large complement of phytochemicals, but without the THC. Hemp, defined as cannabis plants containing <.3% THC, forms the basis for most broad spectrum extracts. Broad spectrum can also be created by either adding terpenes, flavonoids, and minor cannabinoids to CBD isolate, or by removing THC from full spectrum extract via distillation.

It depends on the strength of pet CBD, the weight of your pet, and if your pet uses it every day or only in specific situations. Most pets use 1 bottle every 30-45 days.

Yes. All Pet CBD is made from Hemp and the Farm Bill of 2018 made Hemp products and their derivatives legal.

Dosing will be calculated by the weight of the pet, the strength of pet CBD, the age of the pet, and whether the pet CBD is for general health or a specific concern. Each WildLifeRx purchase comes with a customized dosing schedul specific to your pet.

No. Pet CBD can be used on pets that are well or sick. Pet CBD should not be used as first-line therapy as some symptoms can be associated with a serious medical condition. Although pet CBD can be taken safely with many medications, pets who are taking medication(s) for the following diseases or are currently being treated for cardiopulmonary disease, hypotension, hypertension, tachycardia, respiratory disease, renal disease, hemophilia, are taking sedatives or are pregnant or nursing, should not take pet CBD. Pet CBD should not be taken 36 hours prior- and post-surgery. If you have any concerns, please contact WildlIfeRx. A licensed Veterinary Technician will review your pet's medical records and assist you.

Yes. Do not use if your pet is currently taking: Steroids Anxiety medications Heart medications Liver or kidney medications Beta-blockers Antidepressants Anti-epileptic and seizure medications Antihistamines If your pet has a weaked liver, consult a veterinarian and let them know that you are concidering to give your pet a product that has been known to slightly elevate liver enzymes. If you are uncertain which class of medication your pet is on, contact a Veterinarian. In addition, if your pet will be having surgery, remove the CBD product for three days pre-and post-surgery. It may thin the blood which will interfere with coaguation. Eliminating certain medications/supplements prior to surgery is common. If your pet needs urgent surgery, let the Veterinary team know that your pet has been taking CBD. In additon, not all dental cleanings involve extractions. Once the pet is anesthetized, a cracked tooth may be found and the hygenist will need to remove it, which may cause bleeding. Stop giving CBD 36 hours prior to any scheduled dental cleaning.

As the pet adjusts to the pet CBD, they may appear sleepy and may want to eat more. Whether these side effects are negative may depend on what the concern is. Reducing the dose, adding the dose to a meal, or dividing the pet's meal into smaller multiple meals may decrease those side effects.

Administer directly into the mouth with the provided plastic dropper, or directly in the food bowl or place the amount on top a very small amount of food. When you administer CBD Oil directly on a full bowl of food, it will absorb into the food and may remain trapped inside the food as it proceeds through the pet's digestive system. This is why you may not see any results from CBD. Administration times and timing. If you want 18-hour coverage for your pet, we recommend splitting the recommended usage amount between the morning and evening. Each half of the recommended usage amount is equal to 9 hours of coverage. CBD oil without food may only take a few minutes to take effect. If you need the effect to take place prior to an event, such as an appointment with the groomer, plan the dose accordingly. Increase the dosage amount or strength. Animals have individualized endocannabinoid systems and might need more or less, than what is on the customized dosing schedule. If you feel you are using the products at a quick rate, order a higher strength. It’s also important to note that there have been no known overdoses on CBD. Change to a different brand and use a broad-spectrum CBD. Hemp is grown in a variety of different geographies and in a variety of climates. Much like the Oranges grown in Florida have a higher sugar content due to the wetter climate than those grown in California. There is a study that is published in the US National Library of Medicine a division of the National Institutes of Health that analyzes the DNA of 645 specimens of Cannabis from China, France, Hungary, Africa, and the Netherlands. The results confirm that there is significant DNA variation amount in the specimens that are grown in 1 country vrs. another country. Differences in DNA may equal differences in CBD potential. In addition, broad-spectrum CBD has more terpenes, plant compounds, and flavonoids than full-spectrum CBD which may affect the CBD potential.

Oils are best dropped directly on top of a few bites of food or dropped directly in a pet's bowl (use a plastic dropper not a glass one). Oils contain the most amount of pet CBD ratio per serving per cost and produce the quickest effect. Treats are convenient and can be given without a meal. Treats contain the least amount of pet CBD ratio per serving, are higher in calories, and have a slower effect than the oil. Capsules are another option but pet owners rarely use this option. (If you are interested in capsules, email us and we will get them for you).

No. All of the products sold on WildLifeRx are non-psychoactive. Pet CBD is made from hemp and hemp contains 0.3% or less Tetrahydrocannabinol (THC). Marajuana can contain from 10-25% THC. All THC percentages are clearly displayed in the product description of each product sold on WildLifeRx.

If the desired effect is behavior-related, then you will be looking for less of that particular behavior such as less barking, itching, pacing, seizures, etc. If you don't see a significant difference, increase the dosage or strength, as outlined in the pet-specific dosing schedule that came with your order, and monitor their behavior. (If you misplaced it, email us your pet's first and last name and we will happily send you another one). Certain effects such as a decrease in cancerous tumors and a decrease in joint inflammation associated with osteoarthritis may require diagnostic testing such as viewing a tumor via an ultrasound. Discuss the options with your Veterinarian. In addition, there are different Hemp strains, grown in different geographical areas throughout the United States which may affect the cannabinoids which in turn will affect the receptors involved within the endocannabinoid system. It is possible that your pet may respond differently after switching to a different brand.

At WildLifeRx, each purchase comes with a customized dosing schedule and wellness plan. The information you give us will be forwarded to a WildLifeRx Licensed Veterinary Technician which they will use to develop a dosing schedule and wellness plan specific to your pet's current medical and behavioral concerns.

All products carry a 15-day customer satisfaction guarantee. If you are not satisfied with any of the products, simply pack up the unopened item, securing it from damage, or breakage and return the product to 17602 17th St. #102 Tustin, CA. We are unable to pay for shipping at this time but you will receive a $5.00 credit on your next order. Once we receive the unopened product, we will issue a full refund. We are unable to refund products on opened products but if you feel you have a specific concern, contact us at 714-924-4436 for assistance. Your acceptance of the terms of purchase means you agree to and understand the refund policy including knowledge that the products purchased, whether consumable or topical, contain cannabinoids from hemp oil. All shipments are carefully packed and inspected before leaving our warehouse. Upon delivery of your order, please check your products carefully to ensure they have not been damaged during shipping. Please send us a picture of the damaged product(s) to hello@WildLifeRx.com within 48 hours of receiving the shipment. Include your first and last name and the name of the product(s) that were damaged. You will receive an email instructing you what to do. It is our priority, that all products arrive undamaged.